Port-wine birthmarks (PWBs) are caused by somatic, mosaic mutations in the G protein guanine nucleotide binding protein alpha subunit q (GNAQ) and are characterized by the formation of dilated, dysfunctional blood vessels in the dermis, eyes, and/or brain. Cutaneous PWBs can be treated by current dermatologic therapy, like laser intervention, to lighten the lesions and diminish nodules that occur in the lesion. Involvement of the eyes and/or brain can result in serious complications and this variation is termed Sturge-Weber syndrome (SWS). (...) Some of the biggest hurdles preventing development of new therapeutics are unanswered questions regarding disease biology and lack of models for drug screening. In this review, we discuss the current understanding of GNAQ signaling, the standard of care for patients, overlap with other GNAQ-associated or phenotypically similar diseases, as well as deficiencies in current in vivo and in vitro vascular malformation models. (shrink)

Practically every contemporary mainstream scientist presumes that all aspects of mind are generated by brain activity. We demonstrate the inadequacy of this picture by assembling evidence for a variety of empirical phenomena which it cannot explain. We further show that an alternative picture developed by F. W. H. Myers and William James successfully accommodates these phenomena, ratifies the common sense view of ourselves as causally effective conscious agents, and is fully compatible with contemporary physics and neuroscience.

The people and the value of their experience, by N. T. Pratt.--From kingship to democracy, by J. P. Harland.--Democracy at Athens, by G. M. Harper.--Athens and the Delian League, by B. D. Meritt.--Socialism at Sparta, by P. R. Coleman-Norton.--Tyranny, by M. Mac Laren.--Federal unions, by C. A. Robinson.--Alexander and the world state, by O. W. Reinmuth.--The Antigonids, by J. V. A. Fine.--Ptolemaic Egypt: a planned economy, by S. L. Wallace.--The Seleucids: the theory of monarchy, by G. Downey.--The political status of (...) the independent cities of Asia Minor in the Hellenistic period, by D. Magie.--The ideal states of Plato and Aristotle, by W. J. Oates.--Epilogue, by A. C. Johnson.--Bibliography (p. 225-233).--Index, by H. V. M. Dennis, III. (shrink)

Josiah Royce (1855-1916) was the leading American proponent of absolute idealism, the metaphysical view (also maintained by G. W. F. Hegel and F. H. Bradley) that all aspects of reality, including those we experience as disconnected or contradictory, are ultimately unified in the thought of a single all-encompassing consciousness. Royce also made original contributions in ethics, philosophy of community, philosophy of religion and logic. His major works include The Religious Aspect of Philosophy (1885), The World and the Individual (1899-1901), The (...) Philosophy of Loyalty (1908), and The Problem of Christianity (1913). Royce's friendly but longstanding dispute with William James, known as "The Battle of the Absolute," deeply influenced both philosophers' thought. In his later works, Royce reconceived his metaphysics as an "absolute pragmatism" grounded in semiotics. This view dispenses with the Absolute Mind of previous idealism and instead characterizes reality as a universe of ideas or signs which occur in a process of being interpreted by an infinite community of minds. These minds, and the community they constitute, may themselves be understood as signs. Royce's ethics, philosophy of community, philosophy of religion, and logic reflect this metaphysical position. (shrink)

This Festschrift in Professor Kristeller’s honor consists of contributions by scholars who have had some connection with Columbia University, his "intellectual home in the United States for three decades." It also includes a Tabula Gratulatoria listing many other friends from the United States and Europe. The editor’s opening essay provides an interesting and informative account of this scholar’s academic career, and should be read together with the complete annotated bibliography of his publications through 1974. The latter lists 149 "major publications" (...) and 220 "minor publications." Kristeller’s contributions to the history of Renaissance philosophy are well known to historians of philosophy, and deservedly so. Here reference should be made to his groundbreaking studies on Marsilio Ficino and Pomponazzi, and on others such as Pico della Mirandola and Petrarch, as well as on Renaissance Platonism, Aristotelianism in the Renaissance, Thomism in the Renaissance, Paduan Averroism, and Alexandrism. But he has also contributed greatly to the fields of medieval and Renaissance history, and especially to our understanding of Renaissance humanism, Renaissance music, and Renaissance art. He is universally recognized as one of the world’s foremost authorities on manuscript research, as is witnessed, for example, by the cooperative project, Catalogus Translationum et Commentariorum, which he founded, and by his Iter ltalicum. In all of these enterprises he has set an enviable example for other scholars by the exacting standards and the breadth of his expertise. It is only fitting, then, that the many essays in this Festschrift should reflect the breadth and depth of the scholarship so evident in the man to whom they are dedicated. Limitations of space will only permit us to list them here, with a few remarks reserved for those of more special interest to philosophers and historians of philosophy: Eugene F. Rice, Jr., "The De magia naturali of Jacques Lefèvre d’Etaples" ; Donald R. Kelley, "Louis Le Caron Philosophe", on Le Caron’s effort to bring together jurisprudence and classical, especially Platonic, philosophy; Richard H. Popkin, "The Pre-Adamite Theory in the Renaissance", with fascinating material about theories concerning men before Adam in La Peyrère and widely scattered earlier sources; Richard Lemay, "The Fly against the Elephant: Flandinus against Pomponazzi on Fate", on an unedited attack by an Augustinian Bishop against Pomponazzi’s espousal of the Stoic doctrine of fate; Martin Pine, "Pietro Pomponazzi and the Medieval Tradition of God’s Foreknowledge", on Pomponazzi’s solution to the problem of divine foreknowledge and human freedom inlight of his familiarity with earlier discussions by Boethius, Aquinas, Scotus, and Ockham; F. Edward Cranz, "Editions of the Latin Aristotle Accompanied by the Commentaries of Averroes", helpful to all who wish to consult late fifteenth- and sixteenth-century versions of the Latin Aristotle and especially the Latin Averroes; Josef Soudek, "A Fifteenth-Century Humanistic Bestseller: The Manuscript Diffusion of Leonardo Bruni’s Annotated Latin Version of the Aristotelian Economics" ; Edward P. Mahoney, "Nicoletto Vernia on the Soul and Immortality", which details a radical shift on Vernia’s part from an earlier Averroistic reading of Aristotle; Joan Kelly-Gadol, "Tommaso Campanella: The Agony of Political Theory in the Counter-Reformation", which attempts to account for some of the shifts and inconsistencies in Campanella’s political writings by placing them within the troubled personal and political circumstances of his life; Charles Trinkaus, "Protagoras in the Renaissance: An Exploration" ; Maristella de Panizza Lorch, "Voluptas, molle quoddam et non invidiosum nomen: Lorenzo Valla’s Defense of voluptas in the Preface to his De voluptate" ; Neal W. Gilbert, "Richard de Bury and the ‘Quires of Yesterday’s Sophisms"’, with much interesting material on the medieval tradition of sophismata, especially at Oxford; Malcolm Brown, "A Pre-Aristotelian Mathematician on Deductive Order" ; John H. Randall, Jr., "Paduan Aristotelianism Reconsidered", on evidence for influence of the Italian Aristotelian tradition on Galileo; William F. Edwards, "Niccoló Leoniceno and the Origins of Humanist Discussion of Method" ; C. Doris Hellman, "A Poem on the Occasion of the Nova of 1572" ; Edward Rosen, "Kepler’s Mastery of Greek" ; W. T. H. Jackson, "The Politics of a Poet: The Archipoeta as Revealed by his Imagery" ; John Charles Nelson, "Love and Sex in the Decameron" ; George B. Parks, "Pico della Mirandola in Tudor Translation" ; Richard Harrier, "Invention in Tudor Literature: Historical Perspectives" ; Helene Wieruszowski, "Jacob Burckhardt and Vespasiano da Bisticci " ; Morimichi Watanabe, "Gregor Heimburg and Early Humanism in Germany" ; Raymond de Roover, "Cardinal Cajetan on ‘Cambium’ or Exchange Dealings" ; and a series of text editions with introductions including Julius Kirshner, "Conscience and Public Finance: A Questio disputata of John of Legnano on the Public Debt of Genoa" ; John Mundy, "The Origins of the College of Saint-Raymond at the University of Toulouse" ; Charles B. Schmitt, "Girolamo Borro’s Multae sunt nostrarum ignorantionum causae " ; Guido Kisch, "An Unpublished Consiliumof Johannes Sichardus" ; Patricia H. Labalme, "The Last Will of a Venetian Patrician " ; Felix Gilbert, "The Last Will of a Venetian Grand Chancellor" ; Herbert S. Matsen, "Giovanni Garzoni to Alessandro Achillini : An Unpublished Letter and Defense" ; Theodore E. James, "A Fragment of An Exposition of the First Letter of Seneca to Lucilius Attributed to Peter of Mantua". The editor, his collaborators, and the contributors are all to be commended for the high quality of this volume.—J.F.W. (shrink)

When "Aristotle on Emotion" was first published it showed how discussion within Plato's Academy led to a better understanding of emotional response, and how that understanding influenced Aristotle's work in rhetoric, poetics, politics and ethics. The subject has been much discussed since then: there are numerous articles, anthologies and large portions of books on emotion and related topics. In a new epilogue to this second edition, W.W. Fortenbaugh takes account of points raised by other scholars and clarifies some of his (...) earlier thoughts, focusing on the central issue: how Aristotle conceived of emotional response. Among other matters, he considers laughter, emotion in relation to belief and appearance, the effect of emotion on judgement, and the involvement of pain and pleasure in emotional response. (shrink)

These essays present new analyzes of the central figures of analytic philosophy -- Frege, Russell, Moore, Wittgenstein, and Carnap -- from the beginnings of the analytic movement into the 1930s. The papers do not reflect a single perspective, but rather express divergent interpretations of this controversial intellectual milieu.

It is widely agreed among philosophers of science today that no formal pattern can possibly be found in the origins of scientific theory. There is no such thing as a "logic of discovery," insists this view--a scientific hypothesis is susceptible to methodological critique only in its relation to empirical consequences derived after the hypothesis itself has emerged through a spontaneous creative inspiration. Yet confronted with the tautly directed thrust of theory-building as actually practiced at the cutting edge of scientific research, (...) this romantic denial of method in the genesis of ideas takes on the appearance of myth. It is the contention of this article that as empirical data ramify in logical complexity, they deposit a hard sediment of theory according to a standard inductive pattern so primitively compelling that it must be recognized as one of the primary forms of inferential thought. This process, here called "ontological induction," is a distillation out of unwieldly observed regularities of more conceptually tractable states hypothesized to underlie them, and is the wellspring of our beliefs in theoretical entities. Previous failure to recognize this pattern of induction has undoubtedly been in substantial measure a result of inadequate attention to the structural details of scientific propositions; for in order to exhibit the nature of ontological induction clearly, it is first necessary to make extended forays through sparsely explored methodological terrain--notably, the nature of scientific "variables," the logical form of "laws," and the type-hierarchy of scientific concepts. (shrink)

Efforts to bare the psychonomic nature of the semantic reference (representation) relation have been remarkably scanty; in fact, the only contemporary account developed with any care is the one proposed by Osgood. However, not even Osgood has looked deeply at the difficulties that beset any attempt to analyze reference in terms of common effects appropriately shared by a symbol and its significate.

Subjunctive conditionals have their uses, but constituting the meaning of dispositional predicates is not one of them. More germane is the analysis of dispositions in terms of "bases"--except that past efforts to maintain an ontic gap between dispositions and their bases, while not wholly misguided, have failed to appreciate the semantic birthright of dispositional concepts as a species of theoretical construct in primitive science.

Defends confrontational modes of citizenship as a means to reinvigorate democratic participation and regime accountability. A growing number of people are enraged about the quality and direction of public life, despise politicians, and are desperate for real political change. How can the contemporary neoliberal global political order be challenged and rebuilt in an egalitarian and humanitarian manner? What type of political agency and new political institutions are needed for this? In order to answer these questions, Confrontational Citizenship draws on a (...) broad base of perspectives to articulate the concept of confrontational citizenship. William W. Sokoloff defends extra-institutional and confrontational modes of political activity along with new ways of conceiving political institutions as a way to create political orders accountable to the people. In contrast to many forms of democratic theory, Sokoloff argues that confrontational modes of citizenship (e.g., protest) are good because they increase the accountability of a regime to the people, increase the legitimacy of regimes, lead to improvements in a political order, and serve as a means to vent frustration. The goal is to make the word citizen relevant and dangerous to the settled and closed practices that structure our political world and to provide a hopeful vision of what it means to be politically progressive today. William W. Sokoloff is Associate Professor of Political Science at the University of Texas, Rio Grande Valley. (shrink)

You are, I am sure, just as aware as I am that the operational nodes of a complex problem, the points at which it can be split open to yield nuggets of new insight or achieve lasting advances, often lie in tediously technical details perhaps incomprehensible to all but specialists in the matter and anyways totally lacking in the romance and easy excitement which attract the topic's dilettantes. I would like you to hold fast to this appreciation, for the concerns (...) I shall raise here are technical indeed. They are, however,seminaltechnicalities which, as we seek to fathom them, should fundamentally reshape our comprehension of the logic of confirmation, causal connectedness, and the foundations of statistical inference. In brief, it will be seen that certain powerful everyday intuitions concerning which propositions are confirmationally irrelevant to which others are exceedingly difficult to justify. (shrink)

Designed to provide scientific personnel, policymakers, and the public with a succinct summary of the public aspects of scientific issues, this book focuses on how values and science intersect and how social values can be brought to bear on complex technical enterprises. Themes examined include: (1) relation of science and technology to human values (citing ways science and technology influence social philosophies); (2) changing sociotechnical milieu (describing recent trends toward politicization in technical endeavors); (3) complexion of science and social sciences (...) (surveying the attributes of the social sciences); (4) professionalism and responsibility (exploring the need for stewardship); (5) architectonics of technical trust (examining the interlocking elements of technical trust and focusing on the recombinant DNA controversy); (6) societal guidance of inquiry and application (discussing the possibilities and limits of scientific freedom); (7) systematic assessment for decision making (offering suggestions for dealing with fact/value distinctions); (8) social values and ethics (examining the role of values in decision making); (9) science and technology in the polis (reviewing ways of managing and reducing undue polarization in sociotechnical disputes); and (10) stewardship (suggesting needs and opportunities for exercising technical responsibility). An extensive bibliography is provided. (ML). (shrink)

In the opening to his late essay, Der Gedanke, Frege asserts without qualification that the word "true" points the way for logic. But in a short piece from his Nachlass entitled "My Basic Logical Insights", Frege writes that the word true makes an unsuccessful attempt to point to the essence of logic, asserting instead that "what really pertains to logic lies not in the word "true" but in the assertoric force with which the sentence is uttered". Properly understanding what Frege (...) takes to be at issue here is crucial for understanding his conception of logic and, in particular, what he takes to be its normative status vis-à-vis judgement, assertion, and inference. In this paper, I focus my attention on clarifying the latter claim and Frege's motivations for making it, exposing what I take to be a fundamental tension in Frege's conception of logic. Finally, I discuss whether Frege's deployment of the horizontal in his mature Begriffsschrift helps to resolve this tension. (shrink)